ABRIN POISONING PDF

The seeds of Abrus precatorius contain the highly toxic plant protein abrin. There is no antidote for abrin poisoning. Management, largely supportive, may consist of administering intravenous fluids, anti-emetics, and activated charcoal depending on the time of exposure. We report the presentation of a single case of unintentional abrin poisoning confirmed by the quantitation of l -abrine biomarker. A previously healthy month-old, Her primary manifestations were episodes of forceful emesis that included food particles progressing to clear gastric fluid.

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Biological Toxins and Bioterrorism pp Cite as. Ricin and abrin belong to the group of type 2 ribosome-inactivating protein, which has a heterodimeric structure consisting of an A-chain linked by a disulfide bond to a B-chain. The B-chain facilitates internalization of the A-chain, which then exerts its toxic effects by inhibiting protein synthesis leading to cell death.

These two plant toxins are highly toxic to human, and initial manifestations of ricin or abrin intoxication are generally nonspecific in nature. It is hence difficult to diagnose ricin and abrin poisoning through clinical symptoms alone. In view of their high toxicity, stability, relative ease of production and the worldwide availability of their source plants, ricin and abrin are considered to be potential chem-bio weapons of interests to terrorists.

While the detection of ricin or abrin in adulterated food and beverages is relatively straightforward, the diagnosis of trace levels of either toxin in biofluid samples is challenged by their short half-life in circulation due to efficient sequestering of these toxins into the target organs. Skip to main content. This service is more advanced with JavaScript available.

Advertisement Hide. Reference work entry First Online: 24 December This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access. Ricin A-chain activity on stem-loop and unstructured DNA substrates. Ribosome-mediated folding of partially unfolded ricin A-chain.

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Facts About Abrin

Abrin is a highly toxic protein obtained from the seeds of Abrus precatorius , but poisoning due to ingestion of A precatorius is extremely rare in China. A year-old girl, perfectly healthy before, was admitted to the department of gastroenterology owing to intentional ingestion of 10 crushed A precatorius seeds, with multiple episodes of somnolent and anxious mental status, vomiting, abdominal pain, diarrhea, hematochezia, and hematuria. We immediately took effective measures including gastric lavage, purgation, gastric acid suppression by proton pump inhibitor PPI , liver protection, hemostasis, blood volume and electrolytes resuscitation, continuous renal replacement therapy CRRT , and hemoperfusion HP. Her unwell mental status was improved to the point at which she became conscious and relaxed.

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Abrin and Ricin: Understanding Their Toxicity, Diagnosis, and Treatment

Biological Toxins and Bioterrorism pp Cite as. Ricin and abrin belong to the group of type 2 ribosome-inactivating protein, which has a heterodimeric structure consisting of an A-chain linked by a disulfide bond to a B-chain. The B-chain facilitates internalization of the A-chain, which then exerts its toxic effects by inhibiting protein synthesis leading to cell death. These two plant toxins are highly toxic to human, and initial manifestations of ricin or abrin intoxication are generally nonspecific in nature. It is hence difficult to diagnose ricin and abrin poisoning through clinical symptoms alone. In view of their high toxicity, stability, relative ease of production and the worldwide availability of their source plants, ricin and abrin are considered to be potential chem-bio weapons of interests to terrorists.

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