BIOQUIMICA DE LA HEMOGLOBINA GLICOSILADA PDF

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Diabetes Mellitus tipo 2 con tendencia a la cetosis. Ketosis prone type 2 diabetes KPD. Luciana Concha L. Facultad de Medicina Universidad de Chile. Correspondencia a :.

Ketosis prone type 2 diabetes KPD is presently a well-defined clinical entity, characterized by a debut with severe hyperglycemia and ketoacidosis similar to the presenting form of Type 1 diabetes mellitus DM1. However, it appears in subjects with Type 2 diabetes mellitus DM2 phenotype. This situation is caused by an acute, reversible dysfunction of the beta cell in individuals with insulin resistance.

Once the acute stage subsides, patients behave as having a DM2 and do not require insulin treatment. They should be kept on a diet and oral hypoglycemic drugs due to their susceptibility to have recurrent acute ketotic decompensations. Key words: Type 2 diabetes mellitus; Hypoglycemic agents; Insulin; Ketosis.

Inicia un cuadro caracterizado por polidipsia, poliuria, cansancio y calambres. Se descarta foco infeccioso. Tabla 1. Tabla 2. Actualmente la DTC es reconocida en todas las poblaciones.

Se deben mantener los hipoglicemiantes orales HGO para prevenir la recurrencia de la cetoacidosis Una vez resuelta la etapa aguda, se inicia manejo con insulina en esquemas basal-bolos. Diabetes Care ; Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Geneva: World Health Organization Maturity-onset diabetes of youth in black Americans. N Engl J Med ; Umpierrez GE.

Ketosis-Prone Type 2 Diabetes. Time to revise the classification of diabetes. Diabetes Care ; e Ann Intern Med ; Colloby M. Ketosis-prone diabetes: Identification and management. Journal of Diabetes Nursing ; Update on diagnosis, pathogenesis and management of ketosis prone Type 2 diabetes mellitus.

Diabet Manag ; 1: Rev Med Chile ; Incorrect and incomplete coding and classification of diabetes: a systematic review. Diabetic Med ; Accuracy and predictive value of classification schemes for ketosis prone diabetes. Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes. J Clin Endocrinol Metab ; 88 11 : Ketosis-prone type 2 diabetes in patients of sub-saharan African origin.

Diabetes ; Sulfonylureas treatment prevents recurrence of hyperglycemia in obese African-American patients with a history of hyperglycemic crises. Effects of intravenous glucose load on insulin secretion in patients with ketosis prone diabetes during near-normoglycemia remission. High prevalence of glucose 6 phosphate deshydrogenase deficiency without gene mutations suggests a novel genetic mechanism predisponing to ketosis prone diabetes.

J Clin Endocrinol Metab ; Hyperglycemic crises in adult patients with diabetes. Syndromes of ketosis-prone diabetes mellitus. Endocr Rev ; Recibido el 5 de mayo de , aceptado el 27 de julio de Correspondencia a: Luciana Concha L. Servicios Personalizados Revista. Correspondencia a : Ketosis prone type 2 diabetes KPD is presently a well-defined clinical entity, characterized by a debut with severe hyperglycemia and ketoacidosis similar to the presenting form of Type 1 diabetes mellitus DM1.

Referencias 1. Sin financiamiento.

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