|Published (Last):||17 July 2017|
|PDF File Size:||9.66 Mb|
|ePub File Size:||18.44 Mb|
|Price:||Free* [*Free Regsitration Required]|
To support researchers to publish their research Open Access, deals have been negotiated with various publishers.
Depending on the deal, a discount is provided for the author on the Article Processing Charges that need to be paid by the author to publish an article Open Access.
This study deals with several aspects of the immune system of cyprinid fish. Some observations on the development of cellular and humoral responsiveness in rosy barb Barbus conchonius are described in appendix I. The scale transplantation technique was used for studying cellular immunity. No significant difference in the median survival time MST of allografts was observed in 6 and 9 months old animals 8.
It is concluded that months old animals have the competence to respond to SRBC, but the humeral immune system is not fullgrown till months later. Cellular immunity has cone to complete maturation at 6 months or earlier. For several reasons carp Cyprinus carpio was used in the second part of this study.
First the plaque assay of Jerne had to be modified for carp in order to monitor the humoral immune response at the level of antibody forming cells appendix II. Serum of bream Abramis brama turned out to be a more reliable complement source than allogeneic carp serum. The kidney pro- and mesonephros appeared to be a major antibody producing organ in carp. The temperature-peak day relationship indicated that there are at least 2 steps in the primary immune response of carp differing in temperature sensitivity.
The anamnestic character of the secondary response was gradually lost at lower temperatures. Therefore the development of immunological memory is probably also temperature dependent. In appendix IV the effect of antigen dose and route of administration on the development of immunological memory was studied. Immunization with low antigen doses along the intramuscular route was optimal for the formation of immunological memory. The capacity to mount an enhanced secondary response was specific for the priming antigen and lasted for at least 10 months.
The effect of the antibiotic oxytetracycline oxyTC upon the immune system of carp was investigated appendices V and VI. The suppressive effect of oxyTC on humoral immunity was clearly demonstrable at the level of antigen binding and antibody producing cells. Secondary responses were not significantly inhibited by oxyTC. A careful use of this drug is recommended since oxyTC can exert immunosuppressive effects during a primary response.
There are no comments yet. You can post the first one! Post a comment. Please log in to use this service.
Books by G.T. Rijkers
Samenvatting: Immunologie Rijkers e.a. Hoofdstuk 6 en 7